Showing posts with label archives of dermatology. Show all posts
Showing posts with label archives of dermatology. Show all posts

Tuesday, December 16, 2008

Treatment of Recalcitrant Psoriasis using Indigo Naturalis

Clinical Assessment of Patients With Recalcitrant Psoriasis in a Randomized, Observer-Blind, Vehicle-Controlled Trial Using Indigo Naturalis

Yin-Ku Lin, MD; Chee-Jen Chang, PhD; Ya-Ching Chang, MD; Wen-Rou Wong, MD; Shu-Chen Chang, PhD; Jong-Hwei Su Pang, PhD

Arch Dermatol. 2008;144(11):1457-1464.

Objective To evaluate the efficacy and safety of treatment with indigo naturalis in patients with recalcitrant plaque-type psoriasis.

Design Randomized, observer-blind, vehicle-controlled, intrapatient comparison study.
Setting Ambulatory department of a hospital.

Participants Forty-two outpatients with chronic plaque psoriasis were enrolled in the study from May 1, 2004, to April 30, 2005.
Intervention The patients applied either indigo naturalis ointment or vehicle ointment topically to each of 2 bilaterally symmetrical psoriatic plaque lesions for 12 weeks (depending on the date of enrollment in the study).

Main Outcome Measures The outcomes were assessed using the following criteria: the sum of erythema, scaling, and induration scores and the clearing percentage of the target plaque lesion assessed by 2 blinded observers.

Results Significant reductions in the sum of scaling, erythema, and induration scores (P < .001) (mean score, 6.3 after indigo naturalis treatment vs 12.8 in control subjects) and plaque area percentage (P < .001) (mean percentage, 38.5% after indigo naturalis treatment vs 90% in controls) were achieved with topical application of indigo naturalis ointment. Approximately 31 of 42 patients (74%) experienced clearance or near clearance of their psoriasis in the indigo ointment–treated lesion.

Conclusion Topical indigo naturalis ointment was a novel, safe, and effective therapy for plaque-type psoriasis.

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See this article at:
http://archderm.ama-assn.org/cgi/content/abstract/144/11/1457?lookupType=volpage&vol=144&fp=1457&view=short