Compounds increase production of an insulin-sensitizing hormone from fat cells
THURSDAY, Feb. 5 (HealthDay News) -- Two compounds isolated from herbs used in traditional Chinese medicine increase the production of an insulin-sensitizing hormone from fat cells and improve hyperglycemia, glucose tolerance and insulin resistance in obese mice, according to study findings published in the February issue of Endocrinology.
Aimin Xu, Ph.D., from the University of Hong Kong, and colleagues screened 50 herbs used in traditional Chinese medicine for compounds that enhance adiponectin production by adipocytes.
The investigators identified two structurally related compounds, astragaloside II and isoastragaloside I, from the medicinal herb Radix Astragali. Both compounds increased adiponectin production by adipocytes without affecting other adipokines and had an additive effect on adiponectin production when given with rosiglitazone, an insulin-sensitizing drug, they found. Chronic administration of either drug in obese mice was associated with higher serum adiponectin and improvements in hyperglycemia, glucose tolerance and insulin resistance, the researchers report.
"In conclusion, our results suggest that pharmacological elevation of circulating adiponectin alone is sufficient to ameliorate insulin resistance and diabetes and support the use of adiponectin as a biomarker for future drug discovery," Xu and colleagues write.
Here's a source of Astragali (astragalus):